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Campath as medication was first approved for B-cell chronic lymphocytic leukemia in 2001. It is marketed by Genzyme, which acquired the worldwide rights from Bayer AG in 2009. Genzyme was bought by Sanofi in 2011. In August/September 2012 Campath was withdrawn from the markets in the US and Europe.
CAMPATH (alemtuzumab) is supplied in single-use clear glass vials containing 30 mg of alemtuzumab in 1 mL of solution. Each carton contains three CAMPATH vials (NDC 58468-0357-3) or one CAMPATH vial (NDC 58468-0357-1). Store CAMPATH at 2–8°C (36–46°F). Do not freeze.
Campath pharmacokinetics were characterized in a study of 30 previously treated B-CLL patients in whom Campath was administered at the recommended dose and schedule. Campath pharmacokinetics displayed nonlinear elimination kinetics. After the last 30 mg dose, the mean volume of distribution at steady-state was 0.18 L/kg (range 0.1 to 0.4 L/kg).
Campath (Alemtuzumab) monoclonal antibody therapy side effects, how it's given, how it works, precautions and self care tips for treatment of b-cell chronic lymphocytic leukemia
WARNING. Campath should be administered under the supervision of a physician experienced in the use of antineoplastic therapy. Hematologic Toxicity: Serious and, in rare instances fatal, pancytopenia/ marrow hypoplasia, autoimmune idiopathic thrombocytopenia, and autoimmune hemolytic anemia have occurred in patients receiving Campath therapy.
Campath Distribution Program P.O. Box 220767 Charlotte, NC 28222-0767. Addititional Text and Links, US Campath (alemtuzumab) Distribution Program. Notice of Upcoming Changes to Campath (alemtuzumab) Distribution Program. August 16, 2019.
Medscape - Chronic lymphocytic leukemia and multiple sclerosis dosing for Campath, Lemtrada (alemtuzumab), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.
Alemtuzumab (MabCampath) Find out what alemtuzumab is, how you have it and other important information about having alemtuzumab. Alemtuzumab is a cancer treatment drug and is also known by its brand names Campath or MabCampath.
How to use Campath Vial. Read the Medication Guide, Patient Safety Information Card, and, if available, the Patient Information Leaflet provided by your pharmacist before you start using alemtuzumab and each time you receive treatment with this drug.
Campath ® Oncology A humanized monoclonal antibody to leukocyte antigen CD52, used to manage CLL refractory to standard therapies; it is expressed on lymphocytes and monocytes, but not hematopoietic stem cells